" /> AP-2 Family Transcription Factor - CISMeF





Preferred Label : AP-2 Family Transcription Factor;

NCIt synonyms : AP-2 Family Protein; Activator Protein-2 Family Transcription Factor;

NCIt definition : Activator Protein 2. Originally identified as a cellular transcription factor that binds the enhancer region of SV40. It is encoded by a family of related genes, AP-2 alpha, AP-2 beta, and AP-2 gamma. AP-2 is developmentally regulated and inducible by RET.;

NCIt note : AP-2 family transcription factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. (UniProt);

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31/07/2025


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