AP-2 Family Transcription Factor

Preferred Label : AP-2 Family Transcription Factor;

NCIt synonyms : AP-2 Family Protein; Activator Protein-2 Family Transcription Factor;

NCIt definition : Activator Protein 2. Originally identified as a cellular transcription factor that binds the enhancer region of SV40. It is encoded by a family of related genes, AP-2 alpha, AP-2 beta, and AP-2 gamma. AP-2 is developmentally regulated and inducible by RET.;

NCIt note : AP-2 family transcription factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. (UniProt);

Details

Origin ID

C17545;

UMLS CUI

C1332097;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Transcription Factor Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Regulatory Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Regulation [NCIt concept]
is_chemical_classification_of_gene_product
- Transcription Factor AP-2-Alpha [NCIt concept]
- Transcription Factor AP-2-Beta [NCIt concept]
- Transcription Factor AP-2-Epsilon [NCIt concept]
- Transcription Factor AP-2-Gamma [NCIt concept]

Keyword's position in hierarchy(ies) :

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