" /> Musculin - CISMeF





Preferred Label : Musculin;

NCIt synonyms : MSC; bHLHa22; ABF-1; Activated B-Cell Factor 1; Myogenic Repressor; Activated B-cell Factor-1; Class A Basic Helix-Loop-Helix Protein 22;

NCIt definition : Musculin (206 aa, 22 kDa) is encoded by the human MSC gene. This protein plays a role in both transcriptional regulation and DNA binding.;

NCIt note : MSC is capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro, and forms heterodimers with E2A proteins in vivo. MSC contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. Mice engineered to lack the protein lack muscle structures derived from the first brachial arch. (EntrezGene and OMIM);

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30/07/2025


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