" /> B-Cell Lymphoma 6 Protein - CISMeF





Preferred Label : B-Cell Lymphoma 6 Protein;

NCIt synonyms : LAZ3; B-cell CLL/Lymphoma-6; LAZ-3 Protein; ZNF51; Zinc Finger Protein 51; Cys-His2 Zinc Finger Transcription Factor; BCL6 Protein; B-Cell Lymphoma-6 Protein; BCL5; BCL-6; Zinc Finger and BTB Domain-Containing Protein 27; B-Cell Lymphoma 5 Protein; Protein LAZ-3; BCL-5;

NCIt related terms : BCL6;

NCIt definition : B-cell lymphoma 6 protein (706 aa, 79 kDa) is encoded by the human BCL6 gene. This protein is involved in transcriptional repression, apoptosis regulation and cell cycle progression.;

NCIt note : B-Cell Lymphoma 6 Protein is a zinc finger transcription factor containing an N-terminal POZ domain. It acts as a sequence-specific repressor of transcription and its activity is dependent upon DNA-binding and on the N-terminal region containing the POZ motif. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. Target genes have roles in B-cell activation, B-cell differentiation, inflammation, and cell cycle control. Expression of BCL6 in some B-cells early in the antigen response may skew them toward a germinal center fate, away from a plasma cell fate. The BCL6 gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. (from OMIM, and LocusLink);

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15/05/2024


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