" /> Erythroid Transcription Factor - CISMeF





Preferred Label : Erythroid Transcription Factor;

NCIt synonyms : Globin Transcription Factor 1; NFE1; GF1; GATA Binding Protein 1; ERYF1; GATA1; GF-1; NF-E1 DNA-Binding Protein; Transcription Factor GATA1; Erythrold Transcription Factor 1; GATA-1;

NCIt definition : Erythroid transcription factor (413 aa, 43 kDa) is encoded by the human GATA1 gene. This protein is involved in transcription and erythropoiesis.;

NCIt note : Erythroid transcription factor binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. (UniProt); Encoded by human GATA1 Gene (GATA Family), 413-aa 42.8-kD tissue-specific transcriptional activator GATA-1, a general switch factor for erythroid/megakaryocyte development, contains a conserved central domain of 2 GATA/C4 zinc fingers that recognize the WGATAR motif. The fingers cooperate in specific binding of the consensus DNA sequence (A/T)GATA(A/G) in erythroid genes. The N-finger interacts with zinc finger FOG1 protein, also essential for erythroid/megakaryocyte development. V205M abrogates GATA1 N-finger interaction with FOG. Regulatory feedback by death-receptor ligands results in caspase-mediated GATA1 degradation and impaired erythroblast development. Arg216gly substitution in the GATA1 N-finger causes X-linked thrombocytopenia; reduces GATA1/FOG1 affinity for palindromic GATA sites. (LocusLink, Swiss-Prot, OMIM);

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12/05/2024


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