Early Growth Response Protein 1

Preferred Label : Early Growth Response Protein 1;

NCIt synonyms : Transcription Factor Zif268; Zinc Finger Protein Krox-24; Zinc Finger Protein 225; EGR-1; Nerve Growth Factor-Induced Protein A; NGFI-A; Transcription Factor ETR103; AT225;

NCIt definition : Early growth response protein 1 (543 aa, 58 kDa) is encoded by the human EGR1 gene. This protein is involved in the modulation of both mitogenesis and differentiation through the transcriptional regulation of specified genes.;

NCIt note : Early growth response protein 1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. (UniProt);

Details

Origin ID

C99601;

UMLS CUI

C1447045;

Automatic exact mappings (from CISMeF team)
- Early growth response 1 [OMIM gene]
- early growth response 1 [HGNC gene]
- early growth response protein 1 [MeSH Descriptor]
- early growth response protein 1 [MeSH concept]
- zinc finger protein 225 [HGNC gene]
OMIM relation
- Early growth response 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- EGR1 protein, human [MeSH concept]
- EGR1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EGR1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2H2 Zinc Finger [NCIt concept]
gene_product_is_element_in_pathway
- Androgen Receptor Regulation Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- MAP Kinase Downregulation Pathway [NCIt concept]
- NTRK1/MAPK Signaling Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- PTP4A Family Signaling Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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