POU Domain, Class 2, Transcription Factor 1

Preferred Label : POU Domain, Class 2, Transcription Factor 1;

NCIt synonyms : OCT-1; Octamer-Binding Protein 1; NF-A1; Nuclear Factor III; Octamer-Binding Transcription Factor 1; OTF-1; NF-III; Octamer Transcription Factor-1; Lymphoid-Specific OTF 1; POU2F1;

NCIt definition : POU domain, class 2, transcription factor 1 (743 aa, 76 kDa) is encoded by the human POU2F1 gene. This protein plays a role in the regulation of transcription.;

NCIt note : POU domain, class 2, transcription factor 1 binds to the octamer motif (5'-ATTTGCAT-3') found in the promoter for some snRNA, histone H2B, and immunoglobulin genes. (UniProt);

Details

Origin ID

C17521;

UMLS CUI

C1442824;

Automatic exact mappings (from CISMeF team)
- Pou domain, class 2, transcription factor 1 [OMIM gene]
- Solute carrier family 22 (organic cation transporter), member 1 [OMIM gene]
- fecal antigen-1, normal [MeSH Supplementary Concept]
- nfi transcription factors [MeSH Descriptor]
- organic cation transporter 1 [MeSH Descriptor]
Currated CISMeF NLP mapping
- octamer transcription Factor-1 [MeSH concept]
- octamer transcription factor-1 [MeSH Descriptor]
False automatic mappings
- Neurofibromatosis, type III, mixed central and peripheral [OMIM Phenotype]
OMIM relation
- Pou domain, class 2, transcription factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- POU2F1 protein, human [MeSH concept]
- POU2F1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- POU2F1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Homeobox Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Homeo Domain [NCIt concept]
- POU Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Androgen Receptor Regulation Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Calcium Signaling in the CD4+ TCR Pathway [NCIt concept]
- FOXA1 Transcription Factor Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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