X-Box Binding Protein 1

Preferred Label : X-Box Binding Protein 1;

NCIt synonyms : XBP-1; Tax-Responsive Element-Binding Protein 5; XBP1;

NCIt definition : X-box binding protein 1 (261 aa, 29 kDa) is encoded by the human XBP1 gene. This protein is a bZIP transcription factor that is involved in both the transcription of major histocompatibilty complex class II genes and the response to unfolded proteins and viral infection.;

NCIt note : X-box binding protein 1 binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3. (SwissProt);

Details

Origin ID

C71448;

UMLS CUI

C4083144;

OMIM relation
- X box-binding protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- XBP1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- XBP1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bZIP Domain [NCIt concept]
gene_product_is_element_in_pathway
- FOXA1 Transcription Factor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410 [NCIt concept]

Keyword's position in hierarchy(ies) :

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