" /> T-Cell Acute Lymphocytic Leukemia Protein 1 - CISMeF





Preferred Label : T-Cell Acute Lymphocytic Leukemia Protein 1;

NCIt synonyms : SCL; T-Cell Leukemia/Lymphoma Protein 5; Stem Cell Leukemia Hematopoietic Transcription Factor; TAL-1; Stem Cell Protein; TAL1; Class A Basic Helix-Loop-Helix Protein 17; TAL1 Gene Product; bHLHa17; T-Cell Acute Lymphocytic Leukemia 1 Protein; SCL Transcription Factor;

NCIt definition : T-cell acute lymphocytic leukemia protein 1 (331 aa, 34 kDa) is encoded by the human TAL1 gene. This protein plays a role in transcriptional regulation and hematopoiesis.;

NCIt note : A probable positive hematopoietic transcriptional regulator, TAL1 belongs to the bHLH family and binds DNA as a hetero-dimer with E12 and E47, which recognize the enhancer E-box DNA motif (5'-CANNTG-3'). TAL1 also binds Rhombotin-2 and DRG1. Some T-ALL leukemias involve TAL1 and TCRA gene translocations, t(1;14)(p32;q11). (from SWISS-PROT P17542, OMIM 187040, and NCI);

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15/05/2024


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