Zinc Finger Protein GLI2

Preferred Label : Zinc Finger Protein GLI2;

NCIt synonyms : GLI2 Protein; Glioma-Associated Oncogene Homolog 2 Protein; TAX Helper Protein; GLI2; GLI-KRUPPEL Family Member 2 Protein; GLI Family Zinc Finger Protein 2;

NCIt definition : Zinc finger protein GLI2 (1586 aa, 168 kDa) is encoded by the human GLI2 gene. This protein plays a role in embryonic development and transcriptional regulation.;

NCIt note : Zinc finger protein GLI2 binds to the DNA sequence 5'-GAACCACCCA-3'. (UniProt); A Kruppel family protein, GLI2 Protein contains five DNA-binding zinc finger repeats and is implicated in transduction of the SHH signal. GLI2 is a putative oncogene in the development of human BCC. The expression of GLI2 in skin results in activation of multiple SHH target genes. (from OMIM);

Details

Origin ID

C18048;

UMLS CUI

C0218975;

OMIM relation
- Gli-kruppel family member 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GLI2 protein, human [MeSH concept]
- GLI2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- GLI2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- GLI Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2H2 Zinc Finger [NCIt concept]
gene_product_is_element_in_pathway
- Basal Cell Carcinoma Pathway [NCIt concept]
- Hedgehog Family-Mediated Signaling Pathway [NCIt concept]
- Hedgehog Signaling Events Mediated by Gli Family Proteins [NCIt concept]
- Hedgehog Signaling Pathway [NCIt concept]
- Sonic Hedgehog Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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