Pituitary-Specific Positive Transcription Factor 1

Preferred Label : Pituitary-Specific Positive Transcription Factor 1;

NCIt synonyms : Pituitary-Specific Transcription Factor 1; Growth Hormone Factor 1; Pit-1; POU1F1; POU Domain, Class 1, Transcription Factor 1; GHF-1;

NCIt definition : Pituitary-specific positive transcription factor 1 (291 aa, 33 kDa) is encoded by the human POU1F1 gene. This protein is involved in both the development and function of the pituitary gland.;

NCIt note : Pituitary-specific positive transcription factor 1 binds to the consensus sequence 5'-TAAAT-3'.; Pituitary-specific positive transcription factor 1 is a target of autoantibodies in Thymoma-triggered autoimmune hypopituitarism. (Scientific Reports, 2017; 7: 43060. DOI: 10.1038/srep43060);

NCI Metathesaurus CUI : CL523823;

Details

Origin ID

C133871;

UMLS CUI

C4521279;

Automatic exact mappings (from CISMeF team)
- POU class 1 homeobox 1 [ORDO Gene]
- POU class 1 homeobox 1 [HGNC gene]
- Pou domain, class 1, transcription factor 1 [OMIM gene]
- Solute carrier family 20 (phosphate transporter), member 1 [OMIM gene]
OMIM relation
- Pou domain, class 1, transcription factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- POU1F1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Homeobox Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Homeo Domain [NCIt concept]
- POU Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Fate Control [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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