Transcription Factor EB

Preferred Label : Transcription Factor EB;

NCIt synonyms : Class E Basic Helix-Loop-Helix Protein 35; bHLHe35; TFEB; T-Cell Transcription Factor EB;

NCIt definition : Transcription factor EB (476 aa, 53 kDa) is encoded by the human TFEB gene. This protein plays a role in transcriptional regulation.;

NCIt note : Transcription factor EB binds to E-box sequences (3'-CANNTG-5'), including both the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes and the gamma-E3 box, a subset of E-boxes, which is present in the heavy-chain immunoglobulin enhancer. (UniProt);

Details

Origin ID

C94763;

UMLS CUI

C1448629;

OMIM relation
- T-cell transcription factor eb [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TFEB protein, human [MeSH Supplementary Concept]
- TFEB protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- TFEB Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine Zipper [NCIt concept]
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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