NCIt definition : Protein Dr1 (176 aa, 19 kDa) is encoded by the human DR1 gene. This protein is involved
in the repression of gene transcription.;
NCIt note : TATA-Binding Protein-Associated Phosphoprotein represses both basal and activated
levels of transcription. DR1 phosphorylation affects its interaction with TBP. The
DR1 protein contains a histone fold motif at the amino terminus, a TBP-binding domain,
and a glutamine- and alanine-rich region and represses transcription with DRAP1 by
inhibiting pre-initiation complex formation through interaction with TFIID and DNA.
The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism
in which an altered DNA conformation, together with the formation of higher order
complexes, inhibits the assembly of the preinitiation complex and controls the rate
of RNA polymerase II transcription.;