" /> Protein Dr1 - CISMeF





Preferred Label : Protein Dr1;

NCIt synonyms : Negative Cofactor 2-Beta; NC2-Beta; Downregulator of Transcription 1 TBP-Binding DR1; Down-Regulator of Transcription 1; TATA Box-Binding Protein-Associated Phosphoprotein DR1; DR1 Protein; TATA-Binding Protein-Associated Phosphoprotein;

NCIt definition : Protein Dr1 (176 aa, 19 kDa) is encoded by the human DR1 gene. This protein is involved in the repression of gene transcription.;

NCIt note : TATA-Binding Protein-Associated Phosphoprotein represses both basal and activated levels of transcription. DR1 phosphorylation affects its interaction with TBP. The DR1 protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region and represses transcription with DRAP1 by inhibiting pre-initiation complex formation through interaction with TFIID and DNA. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.;

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31/07/2025


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