Dachshund Homolog 1

Preferred Label : Dachshund Homolog 1;

NCIt synonyms : DACH1;

NCIt related terms : Dachshund-Homolog 1; Dachshund Family Transcription Factor 1; ANNA-3 Antigen; NEURONAL NUCLEAR TYPE 3 AUTOANTIGEN;

NCIt definition : Dachshund homolog 1 (758 aa, 79 kDa) is encoded by the human DACH1 gene. This protein plays a role in both organ development and transcriptional regulation.;

Alternative definition : CDISC: An antigen encoded by the DACH1 gene and regulates gene expression and cell fate determination during development. It can be considered as a neuronal autoantigen and is commonly associated with autoimmune neurodegenerative and paraneoplastic disorders related to cancer.;

NCIt note : Dachshund homolog 1 has been identified as the autoantigen targeted by anti-neuronal nuclear antibody-type 3 (ANNA3; ANNA-3), which is a marker for paraneoplastic neurologic syndrome. (Ann Neurol. 2022;91:670-675.);

PubMed : 35150165;

Details

Origin ID

C200651;

OMIM relation
- Dachshund family transcription factor 1 [OMIM gene]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- DACH1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Organogenesis [NCIt concept]
- Replication-Associated Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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