MAX-Interacting Protein 1

Preferred Label : MAX-Interacting Protein 1;

NCIt synonyms : MXI1; MAX Interacting Protein-1; MAX Dimerization Protein 2; bHLHc11; Class C Basic Helix-Loop-Helix Protein 11; Max Interactor 1; MAX Interacting Protein 1; MAD2;

NCIt definition : Max-interacting protein 1 (228 aa, 26 kDa) is encoded by the human MXI1 gene. This protein plays a role in transcription factor binding and transcriptional repression.;

NCIt note : MAX Interacting Protein 1, encoded by the MXI1 gene, is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function.;

Details

Origin ID

C28556;

UMLS CUI

C0212908;

False automatic mappings
- Mandibuloacral dysplasia [ORDO Disease]
OMIM relation
- Max-interacting protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MXI1 protein, human [MeSH concept]
- MXI1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- MXI1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Heart [NCIt concept]
- Kidney [NCIt concept]
- Liver [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- DNA Binding [NCIt concept]
- Heterodimerization [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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