Forkhead Box Protein K1

Preferred Label : Forkhead Box Protein K1;

NCIt synonyms : FOXK1; Forkhead Box K1; Myocyte Nuclear Factor; MNF;

NCIt definition : Forkhead box protein K1 (733 aa, 75 kDa) is encoded by the human FOXK1 gene. This protein plays a role in the downregulation of autophagy and the upregulation of the expression of enzymes that promote aerobic glycolysis.;

NCIt note : Phosphorylation of forkhead box protein K1 (FOXK1) by glycogen synthase kinase 3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins, which leads to cytoplasmic sequestration of FOXK1. (UniProt);

Details

Origin ID

C205389;

OMIM relation
- Forkhead box k1 [OMIM gene]
gene_encodes_gene_product
- FOXK1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Forkhead Box [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Survival [NCIt concept]
- DNA Binding [NCIt concept]
- Glycolysis [NCIt concept]
- Myogenesis [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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