Telomerase Regulation-Associated Protein

Preferred Label : Telomerase Regulation-Associated Protein;

NCIt synonyms : SCYL1 Isoform 6; SCYL1; TEIF; SCY1-Like Protein 1 Isoform 6; Telomerase Transcriptional Elements-Interacting Factor; Telomerase Transcriptional Element-Interacting Factor;

NCIt definition : Telomerase regulation-associated protein (787 aa, 86 kDa) is encoded by the human SCYL1 gene. This protein plays a role play a role in transcriptional regulation of telomerase reverse transcriptase (TERT).;

NCIt note : Telomerase regulation-associated protein has a catalytically inactive N-terminal kinase domain and the C-terminal domain of this isoform may bind specific DNA promoter sequences to activate transcription of the telomerase reverse transcriptase (TERT) and DNA polymerase beta (POLB) genes. (EntrezGene and UniProt);

NCI Metathesaurus CUI : CL1793006;

Details

Origin ID

C191787;

UMLS CUI

C5780811;

OMIM relation
- Scy1-like 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SCYL1 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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