Transcription Factor MafA

Preferred Label : Transcription Factor MafA;

NCIt synonyms : Pancreatic Beta-Cell-Specific Transcriptional Activator; v-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A; Transcription Factor RIPE3b1;

NCIt definition : Transcription factor MafA (353 aa, 37 kDa) is encoded by the human MAFA gene. This protein plays a role in the activation of insulin gene expression in the pancreas.;

NCIt note : Transcription Factor MafA binds to the insulin enhancer element RIPE3b in pancreatic beta cells.;

Details

Origin ID

C120573;

UMLS CUI

C1436437;

OMIM relation
- Maf bzip transcription factor a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MAFA protein, human [MeSH Supplementary Concept]
- MAFA protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MAFA Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Beta Cell [NCIt concept]
- Islet of Langerhans [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- MAF Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bZIP Domain [NCIt concept]
gene_product_is_element_in_pathway
- Maturity Onset Diabetes of the Young Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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