Forkhead Box Protein G1

Preferred Label : Forkhead Box Protein G1;

NCIt synonyms : BF1 Protein; HFK3; Forkhead Box Protein G1A; HFK2; Forkhead- Related Protein FKHL2; Forkhead- Related Protein FKHL1; BF-2; Forkhead Box Protein G1C; FKHL1; FKHL1 Protein; Brain Factor 1; BF1; BF-1; Forkhead-Related Protein FKHL3; Brain Factor 2; hBF-2; Forkhead Protein G1B; HFK1; BF2; Transcription Factor BF1; Forkhead Box Protein-G1B Protein; FOXG1;

NCIt definition : Forkhead box protein G1 (489 aa, 52 kDa) is encoded by the human FOXG1 gene. This protein is involved in transcriptional regulation, and brain development.;

NCIt note : Forkhead Box Protein G1 acts as transcriptional repressor and belongs to the large FKH/HNF3 family of transcription factors, that includes the Drosophila homeotic FKH and mammalian HNF3 and BF1 proteins. Family members share a unique DNA-binding FKH box. FOXG1 expression is restricted to telencephalic neurons, with strong expression in the dentate gyrus and hippocampus. (OMIM); The original characterization of forkhead box protein G1 inferred that there were 3 related but distinct genes and proteins in this family. Later it was discovered that there was only one gene encoding one protein and that the unique exon structure may have been the cause of sequence inconsistencies. (UniProt);

Details

Origin ID

C17584;

UMLS CUI

C0290266;

OMIM relation
- Forkhead box g1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FOXG1 protein, human [MeSH Supplementary Concept]
- FOXG1 protein, human [MeSH concept]
gene_encodes_gene_product
- FOXG1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Forkhead Box [NCIt concept]
gene_product_is_element_in_pathway
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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