Transcription Factor NF-E2 45 kDa Subunit

Preferred Label : Transcription Factor NF-E2 45 kDa Subunit;

NCIt synonyms : Leucine Zipper Protein NF-E2; Nuclear Factor, Erythroid-Derived 2 45 kDa Subunit; p45 NF-E2;

NCIt definition : Transcription factor NF-E2 45 kDa subunit (373 aa, 41 kDa) is encoded by the human NFE2 gene. This protein plays a role in the regulation of gene expression during blood cell maturation.;

NCIt note : Erythroid transcription activator nuclear factor erythroid-derived 2 (NF-E2), composed of a heterodimer of transcription factor NF-E2 45 kDa subunit and transcription factor MafK, possesses transactivation activity on beta-globin. A heterodimer of transcription factor NF-E2 45 kDa subunit and transcription factor MafG promotes erythropoiesis. (UniProt);

Details

Origin ID

C93118;

UMLS CUI

C2985445;

OMIM relation
- Nuclear factor erythroid 2, p45 subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- NFE2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bZIP Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Blood Circulation [NCIt concept]
- DNA Binding [NCIt concept]
- Erythropoiesis [NCIt concept]
- Megakaryocyte Differentiation [NCIt concept]
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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