" /> Paired Box Protein Pax-2 - CISMeF





Preferred Label : Paired Box Protein Pax-2;

NCIt synonyms : PAX2; PAX-2;

NCIt definition : Paired box protein PAX-2 (417 aa, 45 kD) is encoded by the human PAX2 gene. This soluble, nuclear protein plays a role in transcription by RNA polymerase II and cellular proliferation.;

NCIt note : Presence of PAX2 in tumor cells blocks production of the ERBB2 protein, which fuels tumor growth. An absence or deficiency of PAX2 decreases the effectiveness of tamoxifen. Several new DNA binding sites for Estrogen Receptor were found in the ERBB2 gene, meaning that liganded ER is able to upregulate its own gene. When exposed to tamoxifen, PAX2 binds to ER and ablates this upregulation. The absence of PAX2 may be used to identify patients who will not respond to to tamoxifen, but will respond to alternate therapy, such as aromatase inhibitors. (Nature 2008; 456:663-666).;

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12/05/2024


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