N-Myc Proto-Oncogene Protein

Preferred Label : N-Myc Proto-Oncogene Protein;

NCIt synonyms : MYCN Protein; Neuroblastoma MYC; bHLHe37; NMYC Gene Product; NMYC; N-Myc Protein; Class E Basic Helix-Loop-Helix Protein 37; MYCN;

NCIt definition : N-myc proto-oncogene protein (464 aa, 50 kDa) is encoded by the human MYCN gene. This protein plays a role in the regulation of transcription and DNA binding.;

NCIt note : The MYCN oncogene is amplified in approximately 25% of neuroblastoma tumors and is the most significant negative prognostic factor. In neuroblastoma, the MYCN oncogene directly activates genes required for DNA replication, and this may contribute to neoplastic transformation of these MYCN-amplified tumors. Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma. (from PMID 11861392);

Details

Origin ID

C17379;

UMLS CUI

C1137610;

Currated CISMeF NLP mapping
- N-myc proteins [MeSH concept]
OMIM relation
- Mycn protooncogene, bhlh transcription factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MYCN protein, human [MeSH concept]
- MYCN protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MYCN Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_abnormality
- Protein Deregulation [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- MYC Family Protein [NCIt concept]
gene_product_has_gene_product_variant
- MYCN NP_005369.2:p.P44L [NCIt concept]
- MYCN Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Neuroblastoma [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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