Signal Transducer and Activator of Transcription 4

Preferred Label : Signal Transducer and Activator of Transcription 4;

NCIt synonyms : STAT4; Signal Transducer and Activator of Transcription-4;

NCIt definition : Signal transducer and activator of transcription 4 (748 aa, 86 kDa) is encoded by the human STAT4 gene. This protein is involved in transcriptional activation and signal transduction.;

NCIt note : This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. (LocusLink);

Details

Origin ID

C28665;

UMLS CUI

C1530119;

OMIM relation
- Signal transducer and activator of transcription 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- STAT4 protein, human [MeSH Supplementary Concept]
- STAT4 protein, human [MeSH concept]
- STAT4 transcription factor [MeSH concept]
- stat4 transcription factor [MeSH Descriptor]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- STAT4 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Signal Transducer and Activator of Transcription [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL12/STAT4 Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Crohn Disease [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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