Transcriptional Activator Myb

Preferred Label : Transcriptional Activator Myb;

NCIt synonyms : c-Myb Protein; c-Myb; MYB; Myb Proto-Oncogene Protein; Proto-Oncogene c-Myb;

NCIt definition : Transcriptional activator Myb (636 aa, 71 kDa) is encoded by the human MYB gene. This protein plays a role in transcriptional activation and the regulation of both proliferation and differentiation of hematopoietic cells.;

NCIt note : Transcriptional activator Myb recognizes the sequence 5'-YAAC[GT]G-3'. (UniProt);

NCI Metathesaurus CUI : CL1374645;

Details

Origin ID

C17329;

UMLS CUI

C5196841;

OMIM relation
- Myb protooncogene, transcription factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MYB protein, human [MeSH Supplementary Concept]
- Proto-Oncogene proteins c-myb [MeSH concept]
- Proto-Oncogene proteins c-myb [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MYB Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- DNA Binding Domain [NCIt concept]
- Helix-Turn-Helix Motif [NCIt concept]
gene_product_is_element_in_pathway
- IL2/PI3K Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Acute Lymphoblastic Leukemia [NCIt concept]
- Myeloid Leukemia [NCIt concept]
- Non-Hodgkin Lymphoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- c-Myb mRNA Degrader REM-422 [NCIt concept]

Keyword's position in hierarchy(ies) :

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