Preferred Label : c-Myb mRNA Degrader RGT-61159;
NCIt synonyms : c-Myb RNA Modulator RGT-61159;
NCIt definition : An orally bioavailable, small molecule mRNA modulator of the proto-oncogene c-Myb,
with potential antineoplastic activity. Upon oral administration, c-Myb mRNA degrader
RGT-61159 targets c-Myb RNA and selectively induces the inclusion of the cryptic poison
exon into the c-Myb RNA transcript, resulting in the elimination of c-Myb mRNA transcript.
This inhibits the production of the c-Myb protein. Suppression of c-Myb expression
results in the restoration of normal differentiation pathways, increased antiproliferative
effects, and the induction of apoptosis in tumor cells that overexpress c-Myb. c-Myb,
an oncogenic transcription factor that plays a key role in the regulation of hematopoietic
cell differentiation and proliferation, is dysregulated or overexpressed in a variety
of tumor cell types.;
Molecule name : RGT 61159; RGT-61159;
Origin ID : C210628;
concept_is_in_subset
- has_target
