Preferred Label : c-Myb mRNA Degrader REM-422;
NCIt synonyms : Myb mRNA Inhibitor REM-422; c-Myb mRNA Inhibitor REM-422; Myb mRNA Degrader REM-422;
NCIt definition : An orally bioavailable, small molecule mRNA degrader of the proto-oncogene c-Myb,
with potential antineoplastic activity. Upon oral administration, c-Myb mRNA degrader
REM-422 promotes the inclusion of poison exon into the c-Myb pre-mRNA transcript,
resulting in the degradation of c-Myb mRNA and the reduction of both c-Myb mRNA and
c-Myb protein levels. This may decrease proliferation in tumor cells with c-Myb dysregulation
or overexpression. c-Myb, an oncogenic transcription factor that plays a key role
in the regulation of hematopoietic cell differentiation and proliferation, is dysregulated
or overexpressed in a variety of tumor cell types.;
Molecule name : REM 422; REM-422;
NCI Metathesaurus CUI : CL1922699;
Origin ID : C203508;
UMLS CUI : C5908003;
Semantic type(s)
- concept_is_in_subset
- has_target
