Zinc Finger Protein PLAGL1

Preferred Label : Zinc Finger Protein PLAGL1;

NCIt synonyms : Pleiomorphic Adenoma-Like Protein 1; Pleomorphic Adenoma Gene-Like 1 Protein; LOT-1; Tumor Supressor ZAC; PLAG-Like 1; PLAGL1; Lost on Transformation 1; Tumor Suppressor ZAC; ZAC Tumor Supressor; Pleiomorphic Adenoma-Like Protein-1;

NCIt definition : Zinc finger protein PLAGL1 (463 aa, 51 kDa) is encoded by the human PLAGL1 gene. This protein is involved in cell cycle arrest, promotion of apoptosis and transcriptional regulation.;

NCIt note : Pleomorphic Adenoma-Like Protein 1 contains 7 C2H2-type zinc fingers and inhibits cell proliferation through induction of the p53 apoptosis and cell cycle arrest pathways. PLAGL1 also regulates pituitary adenylate cyclase-activating polypeptide type 1 receptor, a potent insulin secretagogue and mediator of autocrine control of insulin secretion in the pancreatic islets.;

Details

Origin ID

C34064;

UMLS CUI

C0757769;

Automatic exact mappings (from CISMeF team)
- PLAG1 like zinc finger 1 [ORDO Gene]
- Plag1-like zinc finger 1 [OMIM gene]
OMIM relation
- Plag1-like zinc finger 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PLAGL1 protein, human [MeSH concept]
- PLAGL1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- PLAGL1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2H2 Zinc Finger [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients