Twist-Related Protein 2

Preferred Label : Twist-Related Protein 2;

NCIt synonyms : Twist Homolog 2; Dermo-1; Dermis-Expressed Protein 1; Twist-Related bHLH Protein Dermo1; Twist Basic Helix-Loop-Helix Transcription Factor 2; bHLHa39; Class A Basic Helix-Loop-Helix Protein 39; Twist Related Protein 2;

NCIt definition : Twist-related protein 2 (160 aa, 18 kDa) is encoded by the human TWIST2 gene. This protein plays a role in transcriptional regulation and osteogenesis.;

NCIt note : Heterodimeric complexes of twist-related protein 2 bind to the E-box consensus sequence 5'-CANNTG-3' and inhibit transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. (UniProt);

Details

Origin ID

C127916;

UMLS CUI

C1435014;

Automatic exact mappings (from CISMeF team)
- Twist family bhlh transcription factor 2 [OMIM gene]
- Twist-Related Protein 2 [MeSH Descriptor]
- Twist-Related Protein 2 [MeSH concept]
- twist family bHLH transcription factor 2 [ORDO Gene]
OMIM relation
- Twist family bhlh transcription factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TWIST2 protein, human [MeSH Supplementary Concept]
- TWIST2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- TWIST2 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Negative Regulation of Cell Differentiation [NCIt concept]
- Protein Dimerization [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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