Interferon Regulatory Factor 2

Preferred Label : Interferon Regulatory Factor 2;

NCIt synonyms : IRF-2; IRF2; Interferon Regulatory Factor-2;

NCIt definition : Interferon regulatory factor 2 (349 aa, 39 kDa) is encoded by the human IRF2 gene. This protein is involved in the modulation of transcription.;

NCIt note : Interferon Regulatory Factor 2 competitively inhibits IRF1-transcriptional activation of interferons alpha and beta, and perhaps other IRF1-activated genes. IRF2 also functions as a transcriptional activator of histone H4.;

Details

Origin ID

C26626;

UMLS CUI

C1506302;

Currated CISMeF NLP mapping
- interferon regulatory Factor-2 [MeSH Descriptor]
- interferon regulatory Factor-2 [MeSH concept]
OMIM relation
- Interferon regulatory factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IRF2 protein, human [MeSH concept]
- IRF2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- IRF2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- IFN-Beta Enhancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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