Interferon Regulatory Factor 7

Preferred Label : Interferon Regulatory Factor 7;

NCIt synonyms : Interferon Regulatory Factor-7; IRF7; IRF-7;

NCIt definition : Interferon regulatory factor 7 (503 aa, 54 kDa) is encoded by the human IRF7 gene. This protein plays a role in the cellular response to viral infection.;

NCIt note : Interferon regulatory factor 7 has at least 4 isoforms produced by alternative splicing, called IRF7A, IRF7B (beta), IRF7C (gamma) and IRF7H. UniProt considers IRF7A the canonical form. IRF7B and IRF7C are C-terminally truncated variants of IRF7A. IRF7H has a unique N-terminal domain.;

Details

Origin ID

C128883;

UMLS CUI

C1530281;

Automatic exact mappings (from CISMeF team)
- Interferon regulatory factor 7 [OMIM gene]
- interferon regulatory Factor-7 [MeSH Descriptor]
- interferon regulatory Factor-7 [MeSH concept]
- interferon regulatory factor 7 [HGNC gene]
- interferon regulatory factor 7 [ORDO Gene]
OMIM relation
- Interferon regulatory factor 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IRF7 protein, human [MeSH Supplementary Concept]
- IRF7 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- IRF7 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- IFN-Beta Enhancer Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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