Interferon Regulatory Factor 3

Preferred Label : Interferon Regulatory Factor 3;

NCIt synonyms : IRF-3; IRF3; Interferon Regulatory Factor-3;

NCIt definition : Interferon regulatory factor 3 (427 aa, 47 kDa) is encoded by the human IRF3 gene. This protein plays a role in the modulation of both antiviral activity and interferon-stimulated response element promoter activation.;

NCIt note : IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. (EntrezGene);

Details

Origin ID

C26625;

UMLS CUI

C0384768;

Currated CISMeF NLP mapping
- interferon regulatory Factor-3 [MeSH Descriptor]
- interferon regulatory Factor-3 [MeSH concept]
OMIM relation
- Interferon regulatory factor 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IRF3 protein, human [MeSH concept]
- IRF3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- IRF3 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- IFN-Beta Enhancer Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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