Interferon Regulatory Factor 4

Preferred Label : Interferon Regulatory Factor 4;

NCIt synonyms : LSIRF; Lymphocyte-Specific IRF; NF-EM5; Lymphocyte-Specific Interferon Regulatory Factor; Multiple Myeloma Oncogene 1; LSIRF Protein; IRF4 Protein; IRF-4; IRF4; Interferon Regulatory Factor-4;

NCIt related terms : MUM1;

NCIt definition : Interferon regulatory factor 4 (451 aa, 52 kDa) is encoded by the human IRF4 gene. This protein is involved in the mediation of both T-cell activation and interferon-stimulated response element promoter-dependent gene expression.;

NCIt note : The relationship between IRF4 and multiple myeloma is being actively investigated. Studies in multiplel myeloma cells have provided some evidence that the survival of these cells is dependent on the cancer-promoting activities of IRF4. (Story in NCI Cancer Bulletin from June 24, 2008).;

Details

Origin ID

C17926;

UMLS CUI

C0299544;

Currated CISMeF NLP mapping
- interferon regulatory factor-4 [MeSH concept]
- interferon regulatory factor-4 [MeSH Supplementary Concept]
OMIM relation
- Interferon regulatory factor 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IRF4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- IRF4 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- IFN-Beta Enhancer Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- B Cell Proliferation [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Frenlosirsen [NCIt concept]

Keyword's position in hierarchy(ies) :

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