Proto-Oncogene c-Rel

Preferred Label : Proto-Oncogene c-Rel;

NCIt synonyms : REL; REL Protein;

NCIt definition : Proto-oncogene c-Rel (619 aa, 69 kDa) is encoded by the human REL gene. This protein plays a role in both transcriptional regulation and signal transduction.;

NCIt note : REL protein is a product of the REL proto-oncogene and may play a role in differentiation and lymphopoiesis. It belongs to the REL/Dorsal family of transcription factors, containing the REL Homology Region (RHR), that includes NFKB and NF-AT. Some members of this family are regulated by subcellular sequestration in the cytoplasm by members of the IKB protein subfamily of RHR proteins, and are involved in embryonic development and differentiation. (from OMIM 164910 and NCI);

Details

Origin ID

C18508;

UMLS CUI

C0919436;

Automatic exact mappings (from CISMeF team)
- No relatives (finding) [SNOMED CT concept]
- Proto-Oncogene proteins c-rel [MeSH Descriptor]
- Rel protooncogene, nf-kappa-b subunit [OMIM gene]
- Relative [LOINC component]
- Relative (person) [SNOMED CT concept]
- Relative (qualifier value) [SNOMED CT concept]
- Relative to (attribute) [SNOMED CT concept]
- c-rel genes [MeSH concept]
- family [MeSH Descriptor]
- genes, rel [MeSH Descriptor]
- genes, rel [MeSH concept]
- oncogene proteins v-rel [MeSH Descriptor]
- rel [IUPAC Term]
- relative [SNOMED Notion]
- relative [ICPS Descriptor]
- relative [ICPS Descriptor]
- relative [IUPAC Term]
- relatives [MeSH concept]
- transcription factor relb [MeSH Descriptor]
OMIM relation
- Rel protooncogene, nf-kappa-b subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- REL Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- Androgen Receptor Regulation Pathway [NCIt concept]
- Atypical NF-kappaB Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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