Homeobox Protein Hox-A9

Preferred Label : Homeobox Protein Hox-A9;

NCIt synonyms : ABD-B; HOX1.7; Homeobox Protein A9; Homeobox Protein 1G; Homeobox Protein HOXA9; Homeodomain Protein HOXA9; HOXA9 Protein; Hox-1G; HOXA9; HOX1G; Homeobox Protein Hox-1G; Homeobox Protein-A9;

NCIt definition : Homeobox protein Hox-A9 (272 aa, 30 kDa) is encoded by the human HOXA9 gene. This protein is involved in transcriptional regulation that drives embryonic development.;

NCIt note : Homeobox Protein A9 isoforms are class I sequence-specific DNA-binding homeobox transcription factors potentially involved in morphogenesis and myeloid differentiation; expression is spatially and temporally regulated during embryonic development. Frameshifted isoform B contains a distinct C-terminus lacking the homeodomain. HOXA9 acts within a developmental regulatory system that provides specific anterior-posterior positional identity to cells. Associated with acute myeloid leukemogenesis, a chimerically fused in-frame nucleoporin NUP98 amino terminal half to HOXA9 may inhibit differentiation or disrupt nucleocytoplasmic transport. (from LocusLink, Swiss-Prot, OMIM);

Details

Origin ID

C26310;

UMLS CUI

C1568680;

Currated CISMeF NLP mapping
- homeobox protein HOXA9 [MeSH concept]
- homeobox protein HOXA9 [MeSH Supplementary Concept]
OMIM relation
- Homeobox a9 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HOXA9 protein, human [MeSH concept]
- homeobox protein HOXA9 [MeSH Supplementary Concept]
- homeobox protein HOXA9 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HOXA9 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Homeobox Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Homeo Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Acute Myeloid Leukemia [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Maturation [NCIt concept]
- Morphogenesis [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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