Pancreas/Duodenum Homeobox Protein 1

Preferred Label : Pancreas/Duodenum Homeobox Protein 1;

NCIt synonyms : Insulin Upstream Factor 1; Somatostatin-Transactivating Factor 1; Insulin Promoter Factor 1; Glucose-Sensitive Factor; Islet/Duodenum Homeobox-1; GSF; IUF-1; IDX-1; Pancreatic-Duodenal Homeobox Factor 1; PDX-1; STF-1; Homeodomain Transcription Factor IPF1; Somatostatin Transcription Factor 1;

NCIt definition : Pancreas/duodenum homeobox protein 1 (283 aa, 31 kDa) is encoded by the human PDX1 gene. This protein plays a role in the modulation of insulin expression.;

NCIt note : Pancreas/duodenum homeobox protein 1 preferentially binds to the DNA motif 5'-[CT]TAAT[TG]-3'. (UniProt);

Details

Origin ID

C118249;

UMLS CUI

C1528563;

Automatic exact mappings (from CISMeF team)
- Cystatin a [OMIM gene]
- Pancreas/duodenum homeobox protein 1 [OMIM gene]
- Pyruvate dehydrogenase complex, component X [OMIM gene]
- glomerulosclerosis, focal segmental [MeSH Descriptor]
- pancreatic and duodenal homeobox 1 [ORDO Gene]
- pancreatic and duodenal homeobox 1 [HGNC gene]
- pancreatic and duodenal homeobox 1 protein [MeSH concept]
- pancreatic and duodenal homeobox 1 protein [MeSH Supplementary Concept]
- pyruvate dehydrogenase complex component X [ORDO Gene]
OMIM relation
- Pancreas/duodenum homeobox protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PDX1 protein, human [MeSH concept]
gene_encodes_gene_product
- PDX1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Homeo Domain [NCIt concept]
gene_product_is_element_in_pathway
- FOXA2 and FOXA3 Transcription Factor Signaling Pathway [NCIt concept]
- Maturity Onset Diabetes of the Young Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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