Transcription Factor SOX-1

Preferred Label : Transcription Factor SOX-1;

NCIt synonyms : SOX-1; SOX1; SRY-Box Transcription Factor 1;

NCIt related terms : Sox1 Nuclear Antigen; Glial Nuclear Type 1 Autoantigen; GLIAL NUCLEAR TYPE 1 ANTIGEN;

NCIt definition : Transcription factor SOX-1 (391 aa, 39 kDa) is encoded by the human SOX1 gene. This protein is involved in transcriptional regulation that modulates neuronal development.;

Alternative definition : CDISC: An antigen encoded by the Sox1 gene. This protein is a transcription activator and may be involved in neuronal development. It can be considered as an autoantigen and is commonly associated with autoimmune neuropathies.;

NCIt note : Autoantibodies targeting transcription factor SOX-1 are associated with paraneoplastic neurological syndrome.;

Details

Origin ID

C200636;

OMIM relation
- Sry-box 1 [OMIM gene]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SOX1 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_expressed_in_tissue
- Central Nervous System [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Transcription Coactivator [NCIt concept]
gene_product_has_structural_domain_or_motif
- HMG-Box [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Neural Development [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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