POU Domain, Class 3, Transcription Factor 2

Preferred Label : POU Domain, Class 3, Transcription Factor 2;

NCIt synonyms : Octamer-Binding Protein 7; Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3; Oct-7; OTF-7; Brain-2; Brain-Specific Homeobox/POU Domain Protein 2; Brn-2; Octamer-Binding Transcription Factor 7;

NCIt definition : POU domain, class 3, transcription factor 2 (443 aa, 47 kDa) is encoded by the human POU3F2 gene. This protein is involved in the modulation of both cell proliferation and transcription.;

NCIt note : POU domain, class 3, transcription factor 2 binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. This protein positively regulates expression of the genes under the control of both the corticotropin-releasing hormone (CRH) and CRH II promoters. (UniProt);

Details

Origin ID

C98199;

UMLS CUI

C1310510;

OMIM relation
- Pou domain, class 3, transcription factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- POU3F2 protein, human [MeSH concept]
gene_encodes_gene_product
- POU3F2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Homeobox Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Homeo Domain [NCIt concept]
- POU Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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