Tumor Protein 63 Isoform 2

Preferred Label : Tumor Protein 63 Isoform 2;

NCIt synonyms : p51; P51delNalpha; DeltaNp63 Alpha; Delta-N p63-Alpha; Delta Np63 Alpha; DeltaN-Alpha;

NCIt definition : Tumor protein 63 isoform 2 (586 aa, 66 kDa) is encoded by the human TP63 gene. This protein plays a role in the mediation of both transcription and skin development.;

NCIt note : Tumor protein 63 isoform 2 is the product of an alternative promoter and start codon located in exon 3 of the human TP63 gene. It also has an N-terminally truncated transactivation domain. Expression of isoform 2 may be tissue specific and aberrant expression may be associated with head and neck squamous cell carcinoma. (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

NCI Metathesaurus CUI : CL512081;

Details

Origin ID

C128298;

UMLS CUI

C4284135;

Automatic exact mappings (from CISMeF team)
- tumor protein p63 [ORDO Gene]
OMIM relation
- Tumor protein p63 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- TP63 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Histogenic Process [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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