Achaete-Scute Homolog 1

Preferred Label : Achaete-Scute Homolog 1;

NCIt synonyms : ASH-1; Human Achaete-Scute Homolog 1 Protein; bHLHa46; Achaete-Scute Complex Homolog-Like 1 Protein; Achaete-Scute Complex-Like 1 Protein; Achaete-Scute Homolog 1 Protein; ASH1; hASH1; Class A Basic Helix-Loop-Helix Protein 46; ASCL1; Mammalian Achaete-Scute Homolog 1; MASH1; Achaete-Scute Complex-Like-1 Protein; Achaete Scute Protein;

NCIt definition : Achaete-scute homolog 1 (236 aa, 25 kDa) is encoded by the human ASCL1 gene. This protein plays a role in both transcriptional regulation and signal transduction.;

NCIt note : Achaete-scute homolog 1 activates transcription by binding to the E box consensus sequence (5'-CANNTG-3'). (UniProt);

Details

Origin ID

C21321;

UMLS CUI

C0083344;

OMIM relation
- Achaete-scute family bhlh transcription factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ASCL1 protein, human [MeSH concept]
- ASCL1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Pediatric Oncology Target Genes/Proteins Terminology [NCIt concept]
gene_encodes_gene_product
- ASCL1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Neural Development [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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