DNA-Binding Protein Ikaros

Preferred Label : DNA-Binding Protein Ikaros;

NCIt synonyms : IKAROS Family Zinc Finger 1 Protein 1; Lymphoid Transcription Factor LyF-1; IKZF1; ZNFN1A1;

NCIt definition : DNA-binding protein Ikaros (519 aa, 58 kDa) is encoded by the human IKZF1 gene. This protein is a transcriptional enhancer that is involved in B- and T-cell maturation.;

Details

Origin ID

C68732;

UMLS CUI

C2348047;

OMIM relation
- Ikaros family zinc finger 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- IKZF1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_gene_product_variant
- IKZF1 NP_006051.1:p.N159Y [NCIt concept]
- IKZF1 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2H2 Zinc Finger [NCIt concept]
gene_product_is_element_in_pathway
- Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- IKZF1/IKZF3 Protein Degrader GLB-002 [NCIt concept]
- IRAK4/Ikaros/Aiolos Protein Degrader KT-413 [NCIt concept]

Keyword's position in hierarchy(ies) :

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