Preferred Label : IKZF1/IKZF3 Protein Degrader GLB-002;
NCIt synonyms : IKZF1/3 Protein Degrader GLB-002; Ikaros/Aiolos Protein Degrader GLB-002; IKZF1/3 Molecular Glue Protein Degrader GLB-002;
NCIt definition : An orally bioavailable protein degrader of the transcription factors Ikaros (Ikaros
family zinc finger protein 1; IKZF1) and Aiolos (Ikaros family zinc finger protein
3; IKZF3), with potential immunomodulating and antineoplastic activities. Upon oral
administration, IKZF1/IKZF3 protein degrader GLB-002 modulates the E3 (ubiquitin)
ligase and targets IKZF1 and IKZF3 for ubiquitination, and induces proteasome-mediated
degradation of IKZF1 and IKZF3. This reduces the levels of these transcription factors,
which are transcriptional repressors in T-cells, and modulates the activity of the
immune system. This also leads to the downregulation of other proteins, including
interferon regulatory factor 4 (IRF4), which may result in apoptosis and the inhibition
of tumor cell proliferation. IKZF1 and IKZF3 play a key role in B and T-cell differentiation.
IRF4, overexpressed in certain malignancies, is a transcription factor and key regulator
of multiple genes controlling tumor cell survival.;
Molecule name : GLB 002; GLB-002; GLB-A062-B;
NCI Metathesaurus CUI : CL1928600;
Origin ID : C206264;
concept_is_in_subset
- has_target
