Hypoxia-Inducible Factor-1

Preferred Label : Hypoxia-Inducible Factor-1;

NCIt synonyms : HIF-1;

NCIt definition : Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of a 120-kD HIF1-alpha subunit complexed with a 91- to 94-kD HIF1-beta subunit.;

Details

Origin ID

C17690;

UMLS CUI

C0215848;

Currated CISMeF NLP mapping
- Hypoxia-Inducible factor 1 [MeSH concept]
- hypoxia-inducible factor 1 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Hypoxia-Inducible factor 1 [MeSH concept]
- hypoxia-inducible factor 1 [MeSH Descriptor]
gene_product_has_biochemical_function
- Transcription Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Transcriptional Regulation [NCIt concept]
has_gene_product_element
- Aryl Hydrocarbon Receptor Nuclear Translocator [NCIt concept]
- Hypoxia-Inducible Factor 1-Alpha [NCIt concept]
related_to_genetic_biomarker
- ARNT Gene [NCIt concept]
- HIF1A Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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