NCIt definition : A synthetic antisense oligodeoxynucleotide (AS ODN) targeting hypoxia-inducible factor-1alpha
(HIF-1alpha) with potential antineoplastic activity. Anti-HIF-1alpha LNA antisense
oligonucleotide EZN-2968 hybridizes with HIF-1alpha mRNA and blocks t HIF-1 alpha
protein expression, which may result in the inhibition of angiogenesis, the inhibition
of tumor cell proliferation, and apoptosis. HIF-1alpha, normally activated in response
to hypoxia-induced stress, is a key transcription regulator of a large number of genes
important in cellular adaptation to low-oxygen conditions, including angiogenesis,
cell proliferation, apoptosis, and cell invasion.;
Semantic type(s)