" /> HIF1A wt Allele - CISMeF





Preferred Label : HIF1A wt Allele;

NCIt synonyms : Hypoxia-Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) wt Allele; HIF-1alpha; HIF1-ALPHA; MOP1; HIF-1A; PASD8; HIF1; BHLHE78;

NCIt definition : Human HIF1A wild-type allele is located within 14q21-q24 and is approximately 53 kb in length. This allele, which encodes hypoxia-inducible factor 1 alpha protein, is involved in angiogenesis and transcriptional regulation during the cellular adaptive response to hypoxia. Overexpression of the HIF1A gene is associated with several types of cancer such as hepatocellular carcinoma and renal cell carcinoma.;

NCIt note : HIF1A gene expression is induced by cytokines, growth factors and hypoxic conditions. This gene produces two RNA transcript variants via alternative splicing which, in turn, encode two distinct protein isoforms.;

GenBank Accession Number : NM_001530;

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14/05/2024


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