Preferred Label : Diazepinomicin;
NCIt synonyms : 11h-dibenzo(B,E)(1,4)diazepin-11-one, 5,10-dihydro-4,6,8-trihydroxy-10-((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-;
NCIt definition : A potent inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic
activity. Diazepinomicin binds to and inhibits Ras kinase, thereby preventing the
phosphorylation and activation of proteins downstream of the Ras signal transduction
pathway, including serine/threonine kinase RAF (BRAF) and extracellular signal-regulated
kinases 1 and 2 (ERK1 and ERK-2), that play a crucial role in regulating cell growth
and survival. Diazepinomicin also selectively binds to the peripheral benzodiazepine
receptor (BZRP), a receptor highly expressed in certain cancer cells, thus inducing
cell cycle arrest and apoptosis in BZRP-expressing cells. In addition, diazepinomicin
is able to cross the blood-brain barrier, thereby reaching therapeutic concentrations
in the brain.;
UNII : YPH994Y0RF;
InChIKey : SALVHVNECODMJP-GNUCVDFRSA-N;
CAS number : 733035-26-2;
Molecule name : ECO-4601; BU-4664L; TLN-4601;
Chemical formula : C28H34N2O4;
PubMed : 20655882;
Origin ID : C62508;
UMLS CUI : C1527794;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
