Preferred Label : Exarafenib;
NCIt synonyms : B-Raf Inhibitor KIN-2787; pan-Raf Inhibitor KIN-2787;
NCIt definition : An orally available inhibitor of class I, II, and III B-Raf (BRAF) protein kinases,
with potential antineoplastic activity. Upon administration, exarafenib binds to and
inhibits Class I, Class II, or Class III B-Raf mutations. This prevents B-Raf-mediated
signal transduction pathways, which may lead to an inhibition of tumor growth in B-Raf
mutant cells. B-Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway,
which is often deregulated and mutated in human cancers, and plays a key role in tumor
cell proliferation and survival.;
UNII : 2VPX8HL8AB;
CAS number : 2639957-39-2;
Molecule name : KIN 2787; KIN-2787;
NCI Metathesaurus CUI : CL1663470;
Origin ID : C180835;
UMLS CUI : C5706855;
Semantic type(s)
- concept_is_in_subset
- has_target
