Preferred Label : pan-RAF Inhibitor JZP815;
NCIt synonyms : RAF Inhibitor JZP815;
NCIt definition : An orally bioavailable inhibitor of all members of the serine/threonine protein kinase
Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic
activity. Upon oral administration, pan-RAF inhibitor JZP815 selectively binds to
and inhibits the activity of wild-type and mutated forms of Raf, including B-Raf mutations,
and B-Raf fusions. This prevents the activation of Raf-mediated signal transduction
pathways, which may inhibit tumor cell growth. Oncogenic mutations in Raf plays a
key role in the overactivation of the Ras-mitogen-activated protein kinase (MAPK)
pathway and drives tumor cell proliferation and survival.;
Molecule name : JZP-815; JZP 815;
NCI Metathesaurus CUI : CL1904931;
Origin ID : C191648;
UMLS CUI : C5784639;
Semantic type(s)
- concept_is_in_subset
- has_target
