" /> B-Raf/VEGFR-2 Inhibitor RAF265 - CISMeF





Preferred Label : B-Raf/VEGFR-2 Inhibitor RAF265;

NCIt related terms : RAF-265; CHIR-265;

NCIt definition : An orally bioavailable small molecule with potential antineoplastic activity. CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of melanoma. CHIR-265 may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. It is a type of Raf kinase inhibitor and angiogenesis inhibitor.;

UNII : 8O434L3768;

CAS number : 927880-90-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 927880-90-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RAF-265; CHIR-265; RAF 265;

Codes from synonyms : CDR0000488410;

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12/05/2024


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