" /> Naporafenib - CISMeF





Preferred Label : Naporafenib;

NCIt synonyms : pan-RAF Kinase Inhibitor LXH254; Raf Family Kinase Inhibitor LXH254;

NCIt related terms : pan-RAF Inhibitor LXH254;

NCIt definition : An orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, naporafenib binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival.;

UNII : 15JL80DG6H;

InChIKey : UEPXBTCUIIGYCY-UHFFFAOYSA-N;

CAS number : 1800398-38-2;

Molecule name : LXH-254; LXH 254;

NCI Metathesaurus CUI : CL503849;

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Keyword's position in hierarchy(ies) : arborescence

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08/05/2025


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