Preferred Label : RAF Inhibitor DCC-3084;
NCIt synonyms : RAF Dimer Inhibitor DCC-3084; BRAF/CRAF Inhibitor DCC-3084;
NCIt definition : An orally bioavailable central nervous system (CNS)-penetrant switch control inhibitor
of the serine/threonine protein kinase Raf family, with potential antineoplastic activity.
Upon oral administration, RAF inhibitor DCC-3084 targets and binds to BRAF and CRAF
kinases, including BRAF monomeric class I mutation, dimeric class II (Ras-independent)
and class III (Ras-dependent) mutations, BRAF fusions and BRAF/CRAF heterodimers,
specifically at the switch pocket regions, thereby binding both monomers of the RAF
dimers and preventing paradoxical activation that results from unbound monomers. This
prevents the activation of Raf-mediated signal transduction pathways, which may inhibit
tumor cell growth. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK
signaling pathway and are upregulated in a variety of cancer cell types. They play
key roles in tumor cell proliferation and survival.;
Molecule name : DCC-3084; DCC 3084;
NCI Metathesaurus CUI : CL1928661;
Origin ID : C206466;
concept_is_in_subset
- has_target
