Preferred Label : RAF Kinase Inhibitor XL281;
NCIt definition : An orally active, small molecule with potential antineoplastic activity. XL281 specifically
inhibits RAF kinases, located downstream from RAS in the RAS/RAF/MEK/ERK kinase signaling
pathway, which may result in reduced proliferation of tumor cells. RAS mutations may
result in constitutive activation of the RAS/RAF/MEK/ERK kinase signaling pathway,
and have been found to occur frequently in human tumors.;
Molecule name : XL-281;
NCI Metathesaurus CUI : CL371855;
Origin ID : C69135;
UMLS CUI : C2347742;
Semantic type(s)
- concept_is_in_subset
- has_target
